Medical Hypotheses

Medical Hypotheses (2006) 66, 466472 http://intl.elsevierhealth.com/journals/mehy Epilepsy and hemicrania: The dopamine hypotheses Shih-Cheng Chen * Department of Neurology, Tri-Service crocked general Hospital, National Defense Medical Center, No. 325, sectionalization 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, ROC subscribe to 22 family line 2005; accepted 27 September 2005 digest hemicrania and epilepsy argon some(prenominal)(prenominal) chronic recurrent dis erects with paroxysmal attacks. They as well as sh ar some alike(p) risk factors, symptoms, and prophylactic device medications. dopamine has long been postulated to be involved in the pathophysiology of migraine and epileptogenesis, by many load-bearing(a) evidences. However, the eccentric of dopamine is dumb controversial till now. A lack of a all-round(prenominal) hypothetical model whitethorn be one of the reasons. dopamine hypothesis is not a virgin term, but it is proposed to exp lain the pathophysiology and the associated phenomena of these disorders. The hypotheses suggest that, in migraine, there is a low dopamine tone, while there is a extravagantly state of dopamine in generalized epilepsy. But the hebdomadary attacks of headaches and seizures maybe both due to a fall in dopamine activity. Dopamine therefore plays a key role in the gene linkage of neuroendocrine, autonomic system and neuronic activity.

Dopamine agonist is also implied in prophylaxis and neuroprotection in both disorders. c 2005 Elsevier Ltd. All rights reserved.  Introduction Migraine and epilepsy are categorised as paroxysmal disord ers. They are both chronic recurrent disorde! rs with episodic attacks. Besides the two disorders have several equalities and associations, which are listed as follows [1]: 1. They are both conglomerate disorders with periodic character in common. 2. The attacks of headaches and seizures tend to go by typical courses, which may include prodromal phase, aura, and postdrome. 3. There are several similar risk factors, such as stress, alcoholic drink consumption, flow cycle in...If you want to get a full essay, order it on our website: BestEssayCheap.com

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